Novel Electrochemical Flow Injection Procedure for Albendazole Determination using Boron-doped Diamond thin Film Electrode
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2019-05-01 |
| Journal | Journal of Analytical Chemistry |
| Authors | Watthanachaiyapong Janhom, Narabhats Rannurags, Arunee Kongsakphaisal, Wasan Sirisungworwong, Saisunee Liawruangrath |
| Institutions | King Mongkutās Institute of Technology Ladkrabang, Chiang Mai University |
| Citations | 5 |
Abstract
Section titled āAbstractāThe homemade electrochemical cell for electrochemical determination of albendazole using boron-doped diamond (BDD) thin film electrode is developed. Electrochemical activity of albendazole was investigated by cyclic voltammetry in 0.10 M phosphate buffer containing 20% (v/v) methanol at pH 2.5. Using the BDD electrode well-defined and highly reproducible cyclic voltammogram was obtained with current signal-to-background ratio of higher than those obtained from the glassy carbon electrode. Flow injection analysis system with amperometric detection using the homemade thin-layer electrochemical flow-through cell with BDD electrode was studied. The hydrodynamic voltammogram of the drug exhibited single well defined maximum oxidation peak at 0.95 V versus Ag/AgCl. A low detection limit of 2 ppm was obtained. The current-concentration relationship was rectilinear over the concentration range of 3.3ā150 ppm. The proposed method was applied to albendazole tablets with satisfactory results.