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Quantitative Analysis for Bioactive Compounds Derived from Traditional Chinese Medicines and Plants by High-Performance Liquid Chromatography with Electrochemical Detection

MetadataDetails
Publication Date2016-01-01
JournalReview of Polarography
AuthorsA. Kotani, Fumiyo Kusu, Hideki Hakamata
InstitutionsTokyo University of Pharmacy and Life Sciences
AnalysisFull AI Review Included

Technical Documentation & Analysis: High-Sensitivity HPLC-ECD using Diamond Electrodes

Section titled “Technical Documentation & Analysis: High-Sensitivity HPLC-ECD using Diamond Electrodes”

This research validates the use of High-Performance Liquid Chromatography with Electrochemical Detection (HPLC-ECD), specifically utilizing Boron-Doped Diamond (BDD) electrodes, for ultra-sensitive and selective analysis of bioactive compounds in Traditional Chinese Medicines (TCMs) and plant extracts.

  • BDD Superiority: BDD electrodes demonstrated a significantly wider potential window and lower background current compared to Glassy Carbon (GC) electrodes, achieving a 5x improvement in Signal/Background (S/B) ratio for Polymethoxyflavones (PMFs).
  • Ultra-High Sensitivity: The BDD system achieved attomole-level detection of catechins and femtomole-level detection of PMFs, proving its utility for trace analysis in complex matrices.
  • High-Potential Oxidation: BDD was critical for the successful electrochemical oxidation of PMFs (e.g., Nobiletin and Tangeretin) at high positive potentials (+1.4 V to +1.5 V vs. Ag/AgCl), a reaction inaccessible or unstable on conventional carbon electrodes.
  • Dual-Mode Analysis: The development of a novel three-channel HPLC-ECD (3LC-ECD) system allowed for simultaneous quantification of compounds requiring both oxidative (Phenolic Acids, +0.7 V) and reductive (Tanshinones, -0.2 V) detection via column switching.
  • Real-World Application: The methods were successfully applied to quantify trace components (e.g., Aristolochic Acids, PMFs, Flavonoids) in complex samples like green tea, Citrus depressa juice, and herbal extracts (Salvia miltiorrhiza, Scutellariae Radix).

The following hard data points highlight the performance achieved using diamond and carbon electrodes in the HPLC-ECD systems described.

ParameterValueUnitContext
BDD Applied Potential (PMFs Oxidation)+1.45V vs. Ag/AgClRequired for methoxy group oxidation
Nobiletin Oxidation Waves (BDD)+1.4 and +1.5V vs. Ag/AgClTwo distinct oxidation steps observed
GC Applied Potential (Oxidation)+0.6 to +0.7V vs. Ag/AgClCatechins, Phenolic Acids (PHAs)
GC Applied Potential (Reduction)-0.2 to -0.7V vs. Ag/AgClAristolochic Acids (AAs), Tanshinones (TANs)
Epicatechin Detection Limit (S/N=3)0.075fmolUsing 0.2 mm i.d. capillary column
Catechin Detection SensitivityamollevelsAchieved via column downsizing
Aristolochic Acid I (AA1) Detection Limit17pgS/N = 3, using GC electrode
Nobiletin Quantification Range0.48 pg to 0.40 ng-Linear range (r > 0.999)
Nobiletin RSD (n=5)< 3.7%Indoor reproducibility
Column Temperature35 or 40°CStandard HPLC-ECD operation

The high sensitivity and selectivity achieved relied on precise control over the electrochemical cell design and material selection.

  1. Electrode Material Selection: Initial screening utilized Glassy Carbon (GC) electrodes for standard oxidation/reduction reactions. Boron-Doped Diamond (BDD) electrodes were specifically introduced to enable high-potential anodic oxidation of methoxy groups in PMFs, leveraging BDD’s wide potential window.
  2. Flow Cell Optimization: A Wall-jet type flow cell was selected for amperometric detection. This design was crucial for minimizing baseline noise fluctuations caused by pump pulsations, leading to improved Signal/Noise ratio.
  3. Column Downsizing: To maintain analyte concentration and maximize signal intensity, column inner diameters were significantly reduced (down to 0.2 mm i.d. capillary columns), enabling attomole-level detection limits.
  4. Multi-Channel System (3LC-ECD): A column-switching technique was implemented using three pumps (MP1-3) and two switching valves (SV1-2) to direct analytes to three separate electrochemical detectors (D1-D3).
  5. Simultaneous Detection: Detectors D1 and D2 were set to an oxidative potential (+0.7 V) for Phenolic Acids (PHAs), while detector D3 was set to a reductive potential (-0.2 V) for Tanshinones (TANs), allowing for simultaneous analysis of compounds with vastly different redox properties.
  6. Mobile Phase Composition: Mobile phases typically consisted of methanol/water/phosphoric acid mixtures, optimized for reversed-phase ODS columns, ensuring the solvent acted as a suitable electrolyte solution.

The successful replication and extension of this high-sensitivity HPLC-ECD research fundamentally relies on access to high-quality, customized Boron-Doped Diamond (BDD) electrodes. 6CCVD is the expert partner for supplying the necessary MPCVD diamond materials and engineering support.

To replicate the ultra-sensitive PMF analysis and leverage the wide potential window demonstrated in this paper, researchers require Heavy Boron-Doped Polycrystalline Diamond (PCD:BDD).

6CCVD Material RecommendationSpecification & Application
Heavy Boron-Doped PCDRequired for HPLC-ECD Working Electrodes. Provides the necessary wide potential window (critical for oxidation > +1.4 V vs. Ag/AgCl) and low residual current for attomole/femtomole sensitivity.
Optical Grade SCDSuitable for high-purity reference electrodes or specialized electrochemical cells requiring ultra-low defect density and superior surface finish (Ra < 1 nm).
Standard Polycrystalline Diamond (PCD)Can be used as a robust substrate material or for applications requiring large area coverage (up to 125 mm wafers).

The research highlights the need for specialized electrode geometries and precise integration into flow cells. 6CCVD offers comprehensive customization services to meet these exact requirements:

  • Custom Dimensions and Geometry: The paper utilized specific electrode sizes for integration into Wall-jet flow cells. 6CCVD provides custom diamond plates and wafers in dimensions up to 125 mm (PCD) and thicknesses ranging from 0.1 ”m to 500 ”m, allowing for precise electrode fabrication.
  • Advanced Metalization Services: Stable electrical contact is paramount for high-potential applications. 6CCVD offers in-house metalization using materials such as Ti, Pt, Au, Pd, W, and Cu, ensuring robust, low-resistance contacts for working electrodes and reference electrode integration.
  • Ultra-Smooth Polishing: For optimal flow dynamics and minimized surface fouling in HPLC-ECD, 6CCVD guarantees superior polishing, achieving surface roughness (Ra) < 5 nm on inch-size PCD and < 1 nm on SCD.
  • Electrochemical System Design Support: The complexity of the 3LC-ECD system (requiring multiple detectors and specific potential settings) necessitates expert material selection. 6CCVD’s in-house PhD team specializes in diamond electrochemistry and can assist researchers in selecting the optimal BDD doping level and geometry for similar multi-channel HPLC-ECD projects.

For custom specifications or material consultation, visit 6ccvd.com or contact our engineering team directly.

View Original Abstract

High-performance liquid chromatography with electrochemical detection (HPLC-ECD) by voltammetric oxidation on glassy carbon (GC) and boron-doped diamond (BDD) electrodes were performed to determine, respectively, attomole levels of catechins and femtomole levels of polymethoxyflavones. Also, these HPLC-ECD systems were applied to the analysis of green tea and Citrus depressa juice. The HPLC-ECD by voltammetric reduction on GC electrode was applicable to determine aristolochic acids in herbal medicine. Using a column-switching technique, three channel HPLC-ECD (3LC-ECD) has been developed for sensitive and simultaneous determination of phenolic acids (PHAs) and tanshinones (TANs) in Salvia miltiorrhiza. In 3LC-ECD using GC working electrodes, PHAs and TANs eluted from three columns were detected, respectively, at two oxidative (+0.7 V vs. Ag/AgCl) detection channels and at a reductive (-0.2 V vs. Ag/AgCl) detection channel. In conclusion, the present HPLC-ECD system has been characterized as a sensitive and selective analytical method for determining bioactive compounds derived from traditional Chinese medicines and plants.