Square-Wave Voltammetric Determination of Paracetamol and Codeine in Pharmaceutical and Human Body Fluid Samples Using a Cathodically Pretreated Boron-Doped Diamond Electrode
At a Glance
Section titled “At a Glance”| Metadata | Details |
|---|---|
| Publication Date | 2015-01-01 |
| Journal | Journal of the Brazilian Chemical Society |
| Authors | Anderson M. Santos, Fernando Campanhã Vicentini, Patrícia Batista Deroco, Romeu C. Rocha‐Filho, Orlando Fatibello‐Filho |
| Institutions | Universidade Federal de São Carlos |
| Citations | 47 |
Abstract
Section titled “Abstract”Simple, fast, and inexpensive electroanalytical procedures were developed for the determination of codeine (COD) solely and paracetamol (PCT) and COD simultaneously in pharmaceutical formulations and human body fluids.The methods involve the combination of square-wave voltammetry (SWV) with a cathodically pretreated boron-doped diamond electrode and a 0.2 mol L -1 acetate buffer (pH 4.0) solution as the supporting electrolyte.Significantly low limits of detection were obtained for COD solely or PCT and COD simultaneously: 1.19 or 18 and 14 nmol L -1 , respectively.The proposed SWV method was successfully applied in the simultaneous determination of PCT and COD in four samples of pharmaceutical tablets, with results similar (at 98% confidence level) to those obtained using a reference high-performance liquid chromatography (HPLC) method.Additionally, adequate results were obtained when concentrations of PCT and COD were determined in human urine or serum samples by addition-recovery.Clearly, the proposed method is an excellent option for the determination of COD solely or PCT and COD simultaneously.